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Anticoagulants: Phenobarbital lowers the plasma amounts of dicumarol (identify Earlier utilized: bishydroxycoumarin) and causes a lessen in anticoagulant action as measured with the prothrombin time. Barbiturates can induce hepatic microsomal enzymes leading to improved metabolism and lowered anticoagulant reaction of oral anticoagulants (e.Nitschk